Prof. Dr. med Ulrich Loos

KreLo GmbH
Medical Diagnostics
Sedan Straße 14
89077 Ulm

University Clinic of Ulm
In retirement
Robert-Koch-Straße 8
89081 Ulm


Curriculum Vitae


1939 Birth in Insterburg, Ostpreußen
1945 Refugee to Flensburg/Schleswig-Holstein
1952 Resetteled to Pforzheim/Baden-Württemberg
1960 Abitur, Kepler-Gymnasium Pforzheim
1967 Marriage with Li-HungWu, Toronto & Taiwan
3 children: Sabine, Beatrix and Martin

Activities in the Youth

1952-1955 Athletics: champion of the region Nordschwarzwald
1955 Rugby: German tournament champion
1953-1956 Chess: champion Nordschwarzwald, 1955 one win and two remis with chess great champion Wolfgang Unzicker, playing simultaneous fast K.O. games (with 24-12-4 persons)

Theatrical performance, high scoring at contests (Recommendation for acting school of Kammertheater Munich)

Activities in the student time

1961-1967 Cooperation in the „brother-sister“-program for integration of foreign students
1962-1964 Organization and preparation of the lecture „English for medical students“ executed by the English lecturer of the Heidelberg Dolmetscherinstitut
1962 Shake handy with Robert Kennedy

Externships sponsored by the DAAD (Deutscher Akademischer Austauschdienst)

In Ioannina/Greece

Special medicine (Snake/Scorpionbites), obstretics (32 independent assists at birth, partially with small operations)

Durham, UK

Paediatrics (medical care for newborns, e.g. liqor punctures), nephrology

Toronto, Canada

Queens Way General Hospital serving a huge industrial area, besides genrel medicine responsible duties in trauma surgery every third night

Academic Career

1960 Studies of Medicine, University of Heidelberg
1966 Doctor of Medicine: „Methenolon action on lipid and cholesterol metabolism“ (supervisor: Prof., Dr.hc. mult. G. Schettler, University of Heidelberg)
1974 Election as active member of the American Thyroid Association (at that time closed circle to 250 americans only)
1982 Appointment as Privatdozent:“Thyroxine metabolism – basic and clinical studies“ (supervisor: Prof., Dr.hc. mult. E.F. Pfeiffer, University Ulm)
1982-2000 Advanced training courses in Thyroidology and Endocrynology

Promotion of  41 students to doctorate in molecular biology with very good ratings

1983- 2004 Director and organiser of 6 International Scientific Conferences  and in consequence sponsored by the European Union to cary out 3 EU High Level Scientific Conferences ( in Molecular Endocrinology and Thyroidology at Reisensburg Castle, Günzburg
1988 Appointment as Apl. Professor of Medicine, University of Ulm
2001 Foundation of individual enterprise „Innovative Medicine“
2004 Retirement from Clinical Engagement, Science tranfer: Promotion of KreLo GmbH Medical Diagnostics, Ulm

Clinical Career

1971 Director Thyroid Laboratory of the University Ulm
1975 Director thyroid outpatient clinic University Ulm
1980 Director outpatient clinic University Ulm covering all endocrine diseases
Senior adviser of three hospital wards of the endocrine clinic

Research Activities

Thyroid hormones: basic and clinical studies, T4 conversion
1970-1972 Thyrotropin releasing factor: Kinetics and clinical application 1970-1976 Development of chemical and radioimmuno assays for T3 , rT3 and TSH
1973 First description of „Low T3 syndrome“: shifted T4-deiodination to rT3

giving rise to the international research, resulting in an extremely high amount of publications by others

1972-1984 Elucidation of factors at the biochemical level influencing thyroxine conversion in cell culture and in animal experiments as well as in clinical investigations
Molecular biology, gene technology and gene expression
T3 regulation of gene expression
1985-1991 Molecular biological studies on T3 regulated genes such as Spot 14 in cell lines at RNA and protein levels (“proteomics”) Links to Fig. or Lit.Cloning and characterization of T3 receptors (TR), gene regulation by T3 via T3 receptors
1990-1999- Detection of new mutants in TR gene in thyroid hormone resistance syndrome, Molecular and clinical characterization. First detection of “peripheral hyperthyroidism (TR gain of function point mutantations) Link Lit causing hyperthyroidism.
Cloning and characterization of TSH receptor in Graves` disease
1993-1995 First detection of a heritable TSH receptor polymorphism in Graves` Disease, Characterization of the hyperactive signalling
Functional characterization of TSH receptor (TSH-R) autoantibodies in Graves` disease
1997-2006 Expression of the first extractable humanTSH-R functional to TSH and Graves autoantibodies: TSH-R fusion proteines with tags for solid phase assays with chimera for the differentiation of stimulating or blocking TSH-R Ab
Cloning and characterization of the human Sodium/Iodide Symporter (NIS)
1998-2006 Cloning and functional characterization of the promoter of NIS.
Cloning and functional characterization of NIS Upstream Enhancer (NUE)
Detection of NIS expression in breast cancer and demonstration of substances which lead to enhancement and synergistical 18 fold potentiation
Grants for Research Projects
1975-2004 Deutsche Forschungsgemeinschaft supporting basic research
2001-2004 EU High Level Scientific Conferences treating molecular biological events in diseases
2003-2006 EU Project Endomet (thyroid) concerning pollution with plasticizers and their action on the whole endocrine system


Science Transfer Activities

1. Kooperationspreis Wissenschaft/Wirtschaft (Award of the Prize for Cooperation of Science and Commerce) 1999 der Universität Ulm

First production of recombinant human TSH receptor (rTSHR) for the detection of auto antibodies in the diagnosis of Graves` Disease and for the therapeutic application by oral tolerization of autoimmunity in Graves` Disease.

2. 2001 Foundation of the enterprise „Innovative Medicine“ in Ulm, Germany

Research, patenting and consulting are the means of this enterprise in order to set innovations in medicine which should lead to novel therapies of until now hardly treatable diseases.
Targets are autoimmune diseases such as diagnosing and treating  Graves` Disease. Analytical studies of genetically engineered rTSHR.  Design of rTSHR constructs for direct detecting Graves`disease causing autoantibodies. Furthermore, novel therapeutic options are given in cancer diseases by the detection of the sodium/iodide symporter (NIS, the “Iodine Pump”) being expressed in cancers, e.g. in breast cancer and others. The therapeutic techniques and strategies can here be used, which since decades are successfully applied in the treatment of thyroid cancer by diagnosing and eradicating tumors with radioactive iodide. A patent is issued on this strategy.

3. 2004 Foundation of „KreLo GmbH Medical Diagnostics“ in Ulm, Germany

The close to economical application orientated molecular biological research and development, the production and marketing of kits
The bringing in of services for the optimization of in vitro diagnostics in the field of human medicine The development of diagnostic kits for the detection of different types of autoantibodies which are specific for special autoimmune diseases.
Innovation in the diagnosis of Graves` Disease by the establishment of a novel assay for the direct measurement of stimulating disease causing auto antibodies by the novel bridging technology providing for the first time direct detection of TSH receptor autoantibodies with high specificity and sensitivity. We cooperated with SIEMENS health care to transfer our corresponding prototype to their huge automated machines which production (IMMULITE TSI) has a good reputation on the world market.